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Wound Healing Potential of Tillandsia recurvata and Guaiacum officinale in Streptozotocin Induced Type 1 Diabetic Rats

Received: 5 November 2014     Accepted: 18 November 2014     Published: 21 November 2014
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Abstract

One of the major challenges faced by people living with diabetes is the treatment and management of diabetic sores and ulcers. Jamaican Ball Moss (Tillandsia recurvata sp.) and Lignum Vitae (Guaiacum officinale) are indigenous to the West Indian region and have been widely studied and used as ethnomedicinal remedies to treat numerous diseases. The anti-tumor properties of the Ball Moss has been the centre of recent discussions, however, both plants are quite popular among Jamaican folklore medicine as effective anti-inflammatory remedies in the treatment of arthritic and rheumatic conditions. This study evaluated the wound healing potential of Tillandsia recurvata sp. and Guaiacum officinale in an excision wound model of normal and streptozotocin induced type I diabetic rats. Rats were grouped (n=6) with similar weight. Animals were placed into 7 study groups, each with different treatments administered topically. All animals were experimentally wounded on the posterior surface. Normal and diabetic groups were treated with Vaseline (control group), Lignum Vitae and Ball Moss extracts and Neosporin (standard group). Animals treated with Ball Moss showed a reduction by 56 % (normal) and 52 % (diabetic) in wound area while Lignum Vitae resulted in a 47 % (normal rats) and 40.5 % (diabetic rats) reduction. The wound area reduction was significantly higher than that of the control with 32 % and 22 % for normal and diabetic rats respectively. The results obtained indicated that both Ball Moss and Lignum Vitae possess wound healing properties with efficacy similar to that of Neosporin.

Published in American Journal of Biomedical and Life Sciences (Volume 2, Issue 6)
DOI 10.11648/j.ajbls.20140206.12
Page(s) 146-149
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Diabetes, Wound healing, Jamaican Ball Moss

References
[1] Brem H, Tomic-Canic M. Cellular and molecular basis of wound healing in diabetes. J Clin Invest 2007, pp. 1219–1222.
[2] Chithra P, Sajithlal GB, Chandrakasan G. Influence of Aloe vera on the healing of dermal wounds in diabetic rats. Journal of Ethnopharmacology 1998, pp.195-201.
[3] Al Bayaty F, Abdulla M, Abu Hassan MI, Masud M. Wound healing potential by hyaluronate gel in streptozotocin-induced diabetic rats. Scientific Research and Essays 2010, pp. 2756-2760.
[4] Rosenberg LZ, de la Torre J. Wound healing, growth factors. [http://www.emedicine.com/plastic/TOPIC457.HTM]. (2006).
[5] Velander P, Theopold C, Hirsch T, Bleiziffer O, Zuhaili B, Fossum M, et al. Impaired wound healing in an acute diabetic pig model and the effects of local hyperglycemia. Wound Repair Regeneration 2008, pp. 288-293.
[6] Nayak S. Influence of Ethanol Extract of Vinca rosea on Wound Healing in Diabetic Rats. Journal of Biological Sciences 2006, pp. 51-55.
[7] Wesley J, Christina AJM, Chidambaranathan N, Ravikumar K. Wound healing activity of the leaves of Tribulus terrestris (linn) aqueous extract in rats. Journal of Pharmacy Research 2009, pp. 841-843.
[8] Zeitlin IJ, Duwiejua M, Fabiyi A, Gray AI. Antiinflammatory activity in extracts from Guaiacum officinale wood cuts. British Journal of Pharmacology 1994, pp. 180.
[9] Lowe H. Anti-tumor and anti-inflammatory extracts of plant biomass and their uses. United States Patent. Patent number: US20080145464 A1. 2008.
[10] Goodson WH, Hunt TK. Studies of wound healing in experimental diabetes mellitus. J Surg Res1977, pp. 221-27.
[11] Goodson WH, Hunt TK. Wound healing and the diabetic patient. Surg Gynecol Obstet1979, pp. 600-608.
[12] Reiser KM. Nonenzymatic glycation of collagen in aging and diabetes. Proc Soc Expl Biol Med 1998, pp. 23-37.
[13] Johnson A. Towards rapid tissue healing. Plastic Surgical Nursing 1984, pp. 39-40.
[14] Davis R. Inhibitory and stimulatory systems in Aloe vera. Aloe Today Winter, 1992.
[15] Azarkan M, EI Moussaoui A, Van Wuytswinkel D, Dehon G,Looze Y. Fractionation and purification of the enzymes stored in the latex of Carica papaya. Journal of Chromatography B. 2003, pp. 229-238.
[16] Nayak BS, Pereira LMP. Catharanthus roseus flower extract has wound-healing activity in Sprague Dawley rats, BMC Complementary and Alternative Medicine 2006, pp. 41.
[17] Ahmad VU, Perveen S, Bano S. Guaiacin A and B from the Leaves of Guaiacum officinale. Planta Medica 1989, pp. 307-308.
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    Perceval Steven Bahado-Singh, Cliff Kelvin Riley, Henry Isaac Lowe, Charah Tabetha Watson, Andrew O’Brien Wheatley, et al. (2014). Wound Healing Potential of Tillandsia recurvata and Guaiacum officinale in Streptozotocin Induced Type 1 Diabetic Rats. American Journal of Biomedical and Life Sciences, 2(6), 146-149. https://doi.org/10.11648/j.ajbls.20140206.12

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    ACS Style

    Perceval Steven Bahado-Singh; Cliff Kelvin Riley; Henry Isaac Lowe; Charah Tabetha Watson; Andrew O’Brien Wheatley, et al. Wound Healing Potential of Tillandsia recurvata and Guaiacum officinale in Streptozotocin Induced Type 1 Diabetic Rats. Am. J. Biomed. Life Sci. 2014, 2(6), 146-149. doi: 10.11648/j.ajbls.20140206.12

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    AMA Style

    Perceval Steven Bahado-Singh, Cliff Kelvin Riley, Henry Isaac Lowe, Charah Tabetha Watson, Andrew O’Brien Wheatley, et al. Wound Healing Potential of Tillandsia recurvata and Guaiacum officinale in Streptozotocin Induced Type 1 Diabetic Rats. Am J Biomed Life Sci. 2014;2(6):146-149. doi: 10.11648/j.ajbls.20140206.12

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  • @article{10.11648/j.ajbls.20140206.12,
      author = {Perceval Steven Bahado-Singh and Cliff Kelvin Riley and Henry Isaac Lowe and Charah Tabetha Watson and Andrew O’Brien Wheatley and Errol St. Aubyn York Morrison},
      title = {Wound Healing Potential of Tillandsia recurvata and Guaiacum officinale in Streptozotocin Induced Type 1 Diabetic Rats},
      journal = {American Journal of Biomedical and Life Sciences},
      volume = {2},
      number = {6},
      pages = {146-149},
      doi = {10.11648/j.ajbls.20140206.12},
      url = {https://doi.org/10.11648/j.ajbls.20140206.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20140206.12},
      abstract = {One of the major challenges faced by people living with diabetes is the treatment and management of diabetic sores and ulcers. Jamaican Ball Moss (Tillandsia recurvata sp.) and Lignum Vitae (Guaiacum officinale) are indigenous to the West Indian region and have been widely studied and used as ethnomedicinal remedies to treat numerous diseases. The anti-tumor properties of the Ball Moss has been the centre of recent discussions, however, both plants are quite popular among Jamaican folklore medicine as effective anti-inflammatory remedies in the treatment of arthritic and rheumatic conditions. This study evaluated the wound healing potential of Tillandsia recurvata sp. and Guaiacum officinale in an excision wound model of normal and streptozotocin induced type I diabetic rats. Rats were grouped (n=6) with similar weight. Animals were placed into 7 study groups, each with different treatments administered topically. All animals were experimentally wounded on the posterior surface. Normal and diabetic groups were treated with Vaseline (control group), Lignum Vitae and Ball Moss extracts and Neosporin (standard group). Animals treated with Ball Moss showed a reduction by 56 % (normal) and 52 % (diabetic) in wound area while Lignum Vitae resulted in a 47 % (normal rats) and 40.5 % (diabetic rats) reduction. The wound area reduction was significantly higher than that of the control with 32 % and 22 % for normal and diabetic rats respectively. The results obtained indicated that both Ball Moss and Lignum Vitae possess wound healing properties with efficacy similar to that of Neosporin.},
     year = {2014}
    }
    

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  • TY  - JOUR
    T1  - Wound Healing Potential of Tillandsia recurvata and Guaiacum officinale in Streptozotocin Induced Type 1 Diabetic Rats
    AU  - Perceval Steven Bahado-Singh
    AU  - Cliff Kelvin Riley
    AU  - Henry Isaac Lowe
    AU  - Charah Tabetha Watson
    AU  - Andrew O’Brien Wheatley
    AU  - Errol St. Aubyn York Morrison
    Y1  - 2014/11/21
    PY  - 2014
    N1  - https://doi.org/10.11648/j.ajbls.20140206.12
    DO  - 10.11648/j.ajbls.20140206.12
    T2  - American Journal of Biomedical and Life Sciences
    JF  - American Journal of Biomedical and Life Sciences
    JO  - American Journal of Biomedical and Life Sciences
    SP  - 146
    EP  - 149
    PB  - Science Publishing Group
    SN  - 2330-880X
    UR  - https://doi.org/10.11648/j.ajbls.20140206.12
    AB  - One of the major challenges faced by people living with diabetes is the treatment and management of diabetic sores and ulcers. Jamaican Ball Moss (Tillandsia recurvata sp.) and Lignum Vitae (Guaiacum officinale) are indigenous to the West Indian region and have been widely studied and used as ethnomedicinal remedies to treat numerous diseases. The anti-tumor properties of the Ball Moss has been the centre of recent discussions, however, both plants are quite popular among Jamaican folklore medicine as effective anti-inflammatory remedies in the treatment of arthritic and rheumatic conditions. This study evaluated the wound healing potential of Tillandsia recurvata sp. and Guaiacum officinale in an excision wound model of normal and streptozotocin induced type I diabetic rats. Rats were grouped (n=6) with similar weight. Animals were placed into 7 study groups, each with different treatments administered topically. All animals were experimentally wounded on the posterior surface. Normal and diabetic groups were treated with Vaseline (control group), Lignum Vitae and Ball Moss extracts and Neosporin (standard group). Animals treated with Ball Moss showed a reduction by 56 % (normal) and 52 % (diabetic) in wound area while Lignum Vitae resulted in a 47 % (normal rats) and 40.5 % (diabetic rats) reduction. The wound area reduction was significantly higher than that of the control with 32 % and 22 % for normal and diabetic rats respectively. The results obtained indicated that both Ball Moss and Lignum Vitae possess wound healing properties with efficacy similar to that of Neosporin.
    VL  - 2
    IS  - 6
    ER  - 

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Author Information
  • Biotechnology Center, University of the West Indies, Mona Campus, Kingston, Jamaica

  • College of Health Science, University of Technology, Kingston, Jamaica

  • Biotech R&D Institute Ltd, Kingston, Jamaica

  • Biotech R&D Institute Ltd, Kingston, Jamaica

  • Biotechnology Center, University of the West Indies, Mona Campus, Kingston, Jamaica

  • Biotech R&D Institute Ltd, Kingston, Jamaica

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